COLOSPA ( Colofac, Generic Mebeverine ) |
| Manufacturer: | DUPHAR manufactures COLOSPA ( Colofac, Generic Mebeverine ). |
| Uses: | The uses of COLOSPA ( Colofac, Generic Mebeverine ) include:
Category : Antispasmodic; smooth muscle relaxant.
Mebeverine has a direct non-specific relaxant effect on vascular, cardiac, and other smooth muscle. Studies indicate that the spasmolytic activity of mebeverine is not restricted to one particular system, but the compound possesses a polyvalent spasmolytic action in which at least three types of mechanisms are involved:
- a direct musculotropic action involving calcium ion exchange and stabilization of excitable membranes
- a competitive antimuscarinic activity of about 0.05 - 0.1 times that of atropine
- a local anaesthetic activity together with potentiation of sympathetic inhibitory influences due to blockade of noradrenaline uptake into sympathetic nerve endings
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